Biomedical Engineering

Faculty

Aiden Eblimit, Ph.D
Aiden Eblimit, Ph.D.
Research Assistant Professor
Office Location: SERC
Phone: 713-743-2829
Email: aeblimit [at] central [dot] uh [dot] edu

Education: 

Postdoctoral Fellow and Instructor, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston TX, 2003-2017
Ph.D., Pavlov First Saint-Petersburg State Medical University, Russia, 2000
M.S., East China Normal University, China, 1993
B.S., East China Normal University, China, 1990

Research Interests: 

Ocular Gene therapy

DNA nanoparticle technology

Genome editing

Molecular genetics of retinal degenerations

Selected Publications: 

Smriti Zaneveld, Aiden Eblimit, Qingnan Liang, Renae Bertrand,Nathaniel Wu,Hehe Liu, Quynh Nguyen, Jacques Zaneveld, Keqing Wang, Yumei Li and Rui Chen.2018. Gene Therapy Rescues Retinal Degeneration in Receptor Expression-Enhancing Protein 6 Mutant Mice. Hum.Gene.Ther. 2018 Oct 16. doi: 10.1089/hum.2018.078. [Epub ahead of print]

Rachayata Dharmat, Aiden Eblimit, Michael A. Robichaux, Zhixian Zhang, Thanh‑Minh T. Nguyen, Sung Yun Jung, Feng He, Antrix Jain, Yumei Li, Jun Qin, Paul Overbeek, Ronald Roepman, Graeme Mardon, Theodore. Wensel, and Rui Chen.2018. SPATA7 maintains a novel photoreceptor-specificzone in the distal connecting cilium. J. Cell. Biol. 2018 Aug 6;217(8):2851-2865. doi: 10.1083/jcb.201712117. Epub 2018 13.

Aiden Eblimit, Smriti Agrawal, Liu Wei, Kandace Thomas, Keqing Wang,Yumei Li ,Graeme Mardon,Rui Chen. 2018. NMNAT1 E257K Variant, Associated with Leber Congenital Amaurosis (LCA9), Causes a Mild Retinal Degeneration Phenotype. Exp.Eye.Research. 2018 Aug;173:32-43. doi: 10.1016/j.exer.2018.04.010. Epub 2018 Apr 17.

Aiden Eblimit, Smriti Agrawal, Kandace Thomas, Anastassov Ivan Assenov, Tajiguli, Abulikemu, Graeme Mardon, Rui Chen. 2017. Conditional Loss of Spata7 in Photoreceptors Causes Progressive Retinal Degeneration in Mice. Exp.Eye.Research. Oct 31. pii: S0014-4835(17)30435-9. doi: 10.1016/j.exer.2017.10.015. [Epub ahead of print]

Smriti A.Agrawal, Thomas Burgoyne, Aiden Eblimit, James Bellingham, David A. Parfitt, Amelia Lane, Ralph Nic hols, Chinwe Asomugha, Matthew J. Hayes, Peter M. Munro, Mingchu Xu, Keqing Wang, Clare E. Futter, Yumei Li, Rui Chen and Michael E. Cheetham 2017. REEP6 Deficiency Leads to Retinal Degeneration through Disruption of ER Homeostasis and Protein Trafficking. Hum.Mol.Genet. 2017 May 5. doi: 10.1093/hmg/ddx149. [Epub ahead of print]

Mingchu Xu, Yajing (Angela) Xie, Hana Abouzeid, Christopher T. Gordon, Alessia Fiorentino, Zixi Sun, Anna Lehman, Ihab S. Osman, Rachayata Dharmat, Rosa Riveiro-Alvarez, Linda Bapst-Wicht, Darwin Babino, Gavin Arno, Virginia Busetto, Li Zhao, Hui Li, Miguel A. Lopez-Martinez, Liliana F. Azevedo, Laurence Hubert, Nikolas Pontikos, Aiden Eblimit, Isabel Lorda-Sanchez, Valeria Kheir, Vincent Plagnol, Myriam Oufadem, Zachry T. Soens, Lizhu Yang, Christine Bole-Feysot, Rolph Pfundt, Nathalie Allaman- Pillet, Patrick Nitschké, Michael E. Cheetham, Stanislas Lyonnet, Smriti A. Agrawal, Huajin L, Gaëtan Pinton, Michel Michaelides, Claude Besmond, Yumei Li, Zhisheng Yuan, Johannes von Lintig, Andrew R. Webster, Hervé Le Hir, Peter Stoilov, UK Inherited Retinal Dystrophy Consortium, Jeanne Amiel, Alison J. Hardcastle, Carmen Ayuso, Ruifang Sui, Rui Chen*, Rando Allikmets,*, Daniel F. Schorderet.(2017) Recessive Mutations in CWC27, Encoding a Spliceosome-Associated Protein, Cause Retinal Degeneration with or without Additional Developmental Anomalies. American J .Hum.Gen. 100(4):592- 604. doi: 10.1016/j.ajhg.2017.02.008. Epub 2017 Mar 9.

Gavin Arno*, Smriti A. Agrawal*, Aiden Eblimit (second author), James Bellingham, Mingchu Xu,Feng,Wang, Christina Chakarova, David A. Parfitt, Amelia Lane, Thomas Burgoyne, Sarah Hull,Keren J Carss, Alessia Fiorentino, Matthew J. Hayes, Peter M.Munro, Ralph Nicols, Nikolas Pontikos, Graham E Holder, UKIRDC, Chinwe Asomugha, Flucy Raymond, Vincent Plagnol, Michel Michaelides, Alison J.Hardcastle, Yumei Li, Catherine Cukras, Andrew R. Webster,Michael E. Cheetham, Rui Chen. 2016. Mutations in REEP6 cause autosomal recessive Retinitis Pigmentosa. American J. Hum. Genet, 99(6):1305-1315. doi: 10.1016/j.ajhg.2016.10.008.

Jin M, Eblimit Aiden, Pulikkathara M, Corr S, Chen R, Mardon G. 2016. Conditional knockout of retinal determination genes in differentiating cells in Drosophila. FEBS J. 283(15):2754-66. doi: 10.1111/febs.13772.

Li Zhao, Yiyun Chen, Amol Onkar Bajaj, Aiden Eblimit, Mingchu Xu, Zachry T. Soens, Feng Wang, Zhongqi Ge, Sung Yun Jung, Feng He, Yumei Li, Theodore G. Wensel, Jun Qin, Rui Chen. 2016. Integrative subcellular proteomic analysis allows accurate prediction of human disease causing genes. Genome Res. Feb 24. pii: gr.198911.115.

Mingchu Xu, Hiroshi Manya, Zixi Sun, Aiden Eblimit, Irma Lopez, Feng Wang, Takeyuki Yamada, Shan Xu, Li Zhao, Yumei Li, Tamao Endo, Robert K. Ruifang Sui,Koenekoop, Rui Chen. 2016. Mutations in POMGNT1 cause non-syndromic retinitis pigmentosa. Hum.Mol.Genet. Jan 28. pii: ddw022. [Epub ahead of print]

Zachry T. Soens, Yuanyuan Li, Li Zhao, Aiden Eblimit, Rachayata Dharmat, Yumei Li, Yiyun Chen, Mohammed Naqeeb, Norma Fajardo, Irma Lopez, Zhaoxia Sun,Robert K. Koenekoop, and Rui Chen, 2016. Hypomorphic mutations in CLUAP1 cause Leber congenital amaurosis. Genetics. Medicine. doi: 10.1038/gim.2015.205. [Epub ahead of print]

Abulikemu Tajiguli, Mingchu Xu, Ruifang Sui, Keqing Wang, Yumei Li, Aiden Eblimit , Sui Rui Fang, Rui Chen, Haji Akber Aisa. 2016. Next-generation sequencing-based molecular diagnosis of 12 inherited retinal disease probands of Uyghur ethnicity. Scie.Report. Feb 9;6:21384. doi: 10.1038/srep21384.

Mingchu Xu, Aiden Eblimit, Jing Wang, Jianli Li, Feng Wang, Li Zhao, Xia Wang, Ningna Xiao, Yumei Li, Lee-Jun C. Wong, Richard A. Lewis, Rui Chen. 2015. ADIPOR1 is mutated in syndromic retinitis pigmentosa. Hum.Mut. Dec 12. doi: 10.1002/humu.22940. [Epub ahead of print]

Ai den Eblimit , Thanh-Minh T. Nguyen, Yiyun Chen Julian Esteve-Rudd, Hua Zhong, Stef Letteboer, Jeroen van Reeuwijk, David L Simons et al. 2015. Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and proteins trafficking in the retina. Hum.Mol.Genet. 24(6):1584-601.

Hua Zhong, Aiden Eblimit, Yalda Moayedi, Sanford L Boye, Vince A Chiodo, Yiyun Chen, Yumei Li, Ralph M Nichols, William W Hauswirth, et.al. 2015. AAV8(Y733F)-mediated gene therapy preserves photoreceptors and retinal function in a Spata7 knockout mouse model of rod-cone dystrophy. Gene Therapy ,8:619-27.

Mingchu Xu, Violet Gelowani, Aiden Eblimit, Feng Wang, Marielle P. Young, Briana L. Sawyer, Li Zhao, Glen Jenkins, Donnell J. Creel, Keqing Wang, Zhongqi Ge, Hui Wang, Yumei Li, M. Elizabeth Hartnett, and Rui Chen.2015. ATF6 is Mutated in Early-Onset Photoreceptor Degeneration with Macular Involvement. Investigative Ophtha. Visual Science ,6:3889-95.

Adila Tuerxuntayi, Yong-qiang Liu, Ablajan Tulake, Maidina Kabas, Aiden Eblimit and Haji Akber Aisa.2014. Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells. BMC Complement Altern Med. 14:166. Doi: 10.1186/1472-6882-14-166.

Barbara Jusiak, Aiden Eblimit, Nele Haelterman, Rui Chen, and Graeme Mardon. 2012. MAPK target sites of eyes absent are not required for eye development or survival in Drosophila. PLoS One.7(12):e50776.

Hui Wang, Anneke I. den Hollander, Yalda Moayedi, Aiden Eblimit, Yumei Li, Rob W.J. Collin, Carel B. Hoyng, Irma Lopez, Molly Bray, Richard Alan Lewis, James R. Lupski, Graeme Mardon, Robert K. Koenekoop and Rui Chen.2009. Mutations in SPATA7 Cause Leber Congenital Amaurosis and Juvenile Retinitis Pigmentosa. American J. Hum.Genet, 84, 380–387.

Xin Miao Fu, Hui Zhang, Xue Feng Zhang, Yang Cao, Wangwang Jiao, Chong Liu, Yang Song, Aiden Eblimit, Zengyi Chang. 2005. A dual role for the N-terminal region of Mycobacterium tuberculosis Hsp16.3 in self-oligomerization and binding denaturing substrate proteins. J.Biol.Chem. 280, 6337-48.

Xinmiao Fu, Jiao Wang, Aiden Eblimit, and Z-Y. Chang. 2004. Inter-subunit cross- linking suppressed the dynamic oligomeric dissociation of Mycobacterium tuberculosis Hsp16.3 and reduced its chaperone activity. Biochemistry (Moscow), 69, 552-557.

Ai den Eblimit , Xinmiao Fu, Liang Cai Gu,Xiu Guang Feng, and Zeng Yi Chang. 2003. Mycobacterium tuberculosis Hsp16.3 Nonamers are Assembled and Re-assembled via Trimer and Hexamer Intermediates”. J.Mol.Biol. 326, 1013-1023.

Ai den Eblimit, and Zeng Yi Chang. 2003. Alpha-Crystallin promote the assembly of trimeric form of mycobacterium tuberculosis Hsp16.3 in a cell free system. Biochemistry(Moscow), 68, 269-274.

Ai den Eblimit, Xiao Lei Qiu, Jing Chen and Zeng Yi Chang. 2003. Reversible Methionine sulfoxidation of Mycobacterium tuberculosis small heat shock protein Hsp16.3 and its possible role in scavenging oxidants. Biochem. Biophys. Res. Commun. 305, 87-93.

Linag Cai Gu, Aiden Eblimit, Wei Li and Zeng Yi Chang. 2002. Monodisperse Hsp16.3 Nonamer Exhibits Dynamic Dissociation and Reassociation, with the Nonamer Dissociation Prerequisite for Chaperone-like Activity. J.Mol.Biol. 319, 517-526.

Xiu Guang Feng, Su Fang Huang, Xin Miao Fu, Aiden Eblimit, and Zeng Yi Chang. 2002. The reassembling process of the nonameric Mycobacterium tuberculosis small heat-shock protein Hsp16.3 occurs via a stepwise mechanism. Biochem. J. 363,329-334.

A.Emelyanov, G.Fedoseev, O.Krasnoschekova, Ai den Eblimit, T.Trendeleva and P.J.Barnes. 2002. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur. Respir. J. 20, 596-600.

A.Emelyanov, G.Fedoseev, Aiden Eblimit, K.Runiski, A.Fedoulov, A.Karabanov and P.J.Barnes. 2001. Elevated concentration of exhaled hydrogen peroxide in asthmatic patients. Chest, 120, 1136-1139.