Biomedical Engineering

Faculty

Wu
Tianfu Wu, Ph.D.
Associate Professor
Office Location: SERC 2008
Phone: 713-743-0142
Fax: 713-743-0226
Email: twu13 [at] central [dot] uh [dot] edu

Dr. Wu completed his PhD degree at Chinese Academy of Sciences (CAS), and then he received postdoctoral training at Pasteur Institute (Paris, France), Max-Planck-Institute of Bioinorganic Chemistry in Germany and later at the UT Southwestern Medical Center. He joined the BME of UH in the fall of 2013.

Awards and Honors: 

2019 UH GEAR Award (University of Houston)
2016 Lupus Novel Research Award (Lupus Research Institute)
2007 Pilot Research Award (Alliance for Lupus Research)
2006 Novartis Travel Award (Novartis)
2001 Scholarship Max‐Planck Society
1999 National Marine 863 Initiatives Award Chinese Ministry of Science & Technology
1998 Di‐Ao Award (Chinese Academy of Sciences)

Research Interests: 

During the past years, our research has primarily focused on biomarker discovery and therapeutic intervention of autoimmune diseases exemplified by lupus. This complex chronic disease is manifested by (1) hyperproliferation and hyperactivation of immune cells, such as B cells, T cells and myeloid cells; (2) production of high titers of autoantibodies and (3) damage to end organs, i.e. kidney, central nervous system (CNS) and/or heart attacked by inflammatory immune cells and autoantibodies. To find a cure for this devastating disease, the first step is to characterize the molecular basis of the pathogenesis of this disease. Emerging proteomic technologies have allowed us to identify potential novel markers and causative signaling pathways of this disease. It is promising that further development and application of these novel technologies might lead to the identification of early biomarkers, non-invasive biomarkers, surrogate pathology markers, and most importantly, therapeutic targets for this immunological disease. Along this line, our future research aims at the development and fabrication of novel detection systems with high sensitivity, high specificity, high reproducibility and high throughput capacity for disease surveillance. This will include chemical synthesis of nanomaterial-based probes for biomarker detection, and the development of biosensor technology. Finally, end-organ damage causes high mortality, therefore, tissue repair will be another research interest and ultimate aim of our future studies of immunological diseases.

Selected Publications: 

Yuan Y, Qiu J, Lin ZT, Li W, Haley C, Mui UN, Ning J, Tyring SK, Wu T*. Identification of Novel Autoantibodies Associated with Psoriatic Arthritis. Arthritis Rheumatol. 2019 Jan 7. doi: 10.1002/art.40830. [Epub ahead of print] PMID: 30618213. *Corresponding author. Impact factor = 9.002

Ye Y, Wu T*, Zhang T, Han J, Habazi D, Saxena R, Mohan C*. Elevated oxidized lipids, anti-lipid autoantibodies and oxidized lipid immune complexes in active SLE. Clin Immunol. 2019 May 7;205:43-48. doi: 10.1016/j.clim.2019.05.004. [Epub ahead of print] PMID: 31075396. *Corresponding author. Impact factor = 3.548

Quan L*, Gu J, Lin W, Wei Y, Lin Y, Liu L, Ding H, Pan C, Xie Z*, Wu T*. A BODIPY biosensor to detect and drive self-assembly of diphenylalanine. Chem Commun (Camb). 2019 Jul 4. doi: 10.1039/c9cc03810h. [Epub ahead of print] PMID: 31271158. *Corresponding author. Impact factor = 6.290

Lin ZT, Li Y, Gu J, Wang H, Zhu Z, Hong X, Zhang Z, Lu Q, Qiu J, Wang X, Bao J, Wu T*. A Conductive Nanowire-mesh Biosensor for Ultrasensitive Detection of Serum C-reactive Protein in Melanoma. 2018. Adv. Funct. Mater. 2018 June 5, DOI: 1002/adfm.201802482. 28(31) *Corresponding author Impact factor = 15.621

Ding H, Wu T*. Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases. Front Endocrinol (Lausanne). 2018 Aug 30;9:499. doi: 10.3389/fendo.2018.00499. eCollection 2018. Review. PMID: 30214426. *Corresponding author. Impact factor = 3.675.

Li C, Yu J, Xu S, Jiang S, Xiu X, Chen C, Liu A, Wu T, Man B, Zhang C. Constructing 3D and Flexible Plasmonic Structure for High-Performance SERS Application. 2018. Adv. Mater. Technol. 2018 Aug, DOI: 10.1002/admt.201800174. Impact factor = 4.787

Guo Y, Yu J, Li C, Li Z, Pan J, Liu A, Man B, Wu T, Xiu X, Zhang C. SERS substrate based on the flexible hybrid of polydimethylsiloxane and silver colloid decorated with silver nanoparticles. 2018. OPTICS EXPRESS 26 (17) 21784 Impact factor = 3.356

Li M, Li X, Liu Y, Liu X, Song Y, Zhao J, Mohan C, Wu T, Peng A, Qin L. Relationship between serum bilirubin levels and the progression of renal function in patients with chronic kidney disease and hyperuricemia. Clin Chim Acta. 2018 Aug 1;486:156-161. doi: 10.1016/j.cca.2018.07.045. [Epub ahead of print] Impact factor = 2.873

Qiu J, Keyser B, Lin ZT, Wu T*. Autoantibodies as Potential Biomarkers in Breast Cancer. Biosensors. 2018, 8, 67. *corresponding author. Impact factor = 3.59

Hong X, Jiang S, Marmolejo N, Vangipuram R, Ramos-Rojas E, Yuan Y, Lin ZT, Li Y, Qiu J, Xing Y, Haley C, Tyring SK, Wu T*. Serum VEGFR-3 as a potential biomarker in psoriasis. Exp Dermatol. 2018 Jun 29. doi: 10.1111/exd.13727. [Epub ahead of print] *Corresponding author Impact factor = 2.67

Li Y, Wu T*. Proteomic approaches for novel systemic lupus erythematosus (SLE) drug discovery. Expert Opin Drug Discov. 2018 Jun 4:1-13. doi: 10.1080/17460441. 2018.1480718. [Epub ahead of print] PMID: 29863906 *Corresponding author. Impact factor = 3.846

Lin ZT, DeMarr V, Bao J, Wu T* Molecularly Imprinted Polymer-Based Biosensors: For the Early, Rapid Detection of Pathogens, Biomarkers, and Toxins in Clinical, Environmental, or Food Samples. IEEE Nanotechnology Magazine 2018, 12 (1), 6-13 *Corresponding author.

Lin ZT, Gu J, Li CH, Lee TR, Xie L, Chen S, Cao PY, Jiang S, Yuan Y, Hong X, Wang H, Wang D, Wang X, Jiang GB, Heon M, Wu T*. A Nanoparticle-Decorated Biomolecule-Responsive Polymer Enables Robust Signaling Cascade for Biosensing. Adv Mater. 2017 Jun 14. doi: 10.1002/adma.201702090. [Epub ahead of print] PMID: 28612952. *Corresponding author. Impact factor = 25.809

Yuan Y, Lin ZT, Wang H, Hong X, Heon M, Wu T*: Protein Arrays I: Antibody Arrays. Methods Mol Biol 2017, 1654:261-269. PMID: 28986797. *Corresponding author.

Yuan Y, Wang H, Lin ZT, Hong X, Heon M, Wu T*: Protein Arrays II: Antigen Arrays. Methods Mol Biol 2017, 1654:271-277. PMID: 28986798. *Corresponding author.

Yuan Y, Hong X, Lin ZT, Wang H, Heon M, Wu T*: Protein Arrays III: Reverse-Phase Protein Arrays. Methods Mol Biol 2017, 1654:279-289. PMID: 28986799. *Corresponding author.

Selvam AP, Wangzhou A, Jacobs M, Wu T, Mohan C, Prasad S. Development and validation of an impedance biosensor for point-of-care detection of vascular cell adhesion molecule-1 toward lupus diagnostics. Future Sci. OA 2017 FSO224 eISSN 2056-5623.

Huang JF*, Zhong J*, Chen GP*, Lin ZT*, Deng Y, Liu YL, Cao PY, Wang B, Wei Y, Wu T, Yuan J, Jiang GB. A Hydrogel-Based Hybrid Theranostic Contact Lens for Fungal Keratitis. ACS Nano. 2016 May 31. [Epub ahead of print] PMID: 27244244 *Co-first authors. Impact factor = 13.94

Wang H, Lin ZT, Yuan Y, Wu T*. Urine biomarkers in renal allograft. J Transl Int Med. 2016 Sep 1;4(3):109-113. PMID: 28191531. *Corresponding author.

Zhang X, Zambrano A, Lin ZT, Xing Y, Rippy J, Wu T*. Immunosensors for Biomarker Detection in Autoimmune Diseases. Arch Immunol Ther Exp (Warsz). 2016 Sep 3. [Epub ahead of print] Review. PMID: 27592176. *Corresponding author Impact factor = 2.0

Wang Q, Liu S, Hu D, Wang Z, Wang L, Wu T, Wu Z, Mohan C & Peng A. Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model 2016, Life Sciences, vol 157, pp. 116-124. Impact factor = 2.7

Orme JJ, Du Y, Vanarsa K, Wu T, Satterthwaite AB, Mohan C. Leukocyte Beta-Catenin Expression Is Disturbed in Systemic Lupus Erythematosus. PLoS One. 2016 Aug 22; 11(8):e0161682. doi: 10.1371/journal.pone.0161682. eCollection 2016. PMID: 27548498 Impact factor = 2.8

Orme JJ, Du Y, Vanarsa K, Mayeux J, Li L, Mutwally A, Arriens C, Min S, Hutcheson J, Davis LS, Chong BF, Satterthwaite AB, Wu T, Mohan C. Heightened Cleavage of Axl Receptor Tyrosine Kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clin Immunol. 2016 May 26. pii: S1521-6616(16)30084-5. doi: 10.1016/j.clim.2016.05.011. [Epub ahead of print] PMID: 27237127 Impact factor = 3.38

Wu T *, Ding H, Han J, Arriens C, Wei C, Han W, Pedroza C, Jiang S, Anolik J, Petri M, Sanz I, Saxena R, Mohan C*. Antibody array based proteomic screening of serum markers in systemic lupus erythematosus – a discovery study. J Proteome Res. 2016 May 23. [Epub ahead of print] PMID: 27211902 *Corresponding authors. Impact factor = 4.268

Du Y, Wu T, Zhou XJ, Davis LS, Mohan C. Blockade of CD354 (TREM-1) Ameliorates Anti-GBM-Induced Nephritis. Inflammation. 2016 Apr 15. [Epub ahead of print] PMID: 27083877. Impact factor = 2.955

Wu T, Xie C, Han J, Ye Y, Singh S, Zhou J, Li Y, Ding H, Li QZ, Zhou X, Putterman C, Saxena R, Mohan C. Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. PLoS One. 2016 Mar 28; 11(3):e0151491. doi: 10.1371/journal.pone.0151491. PMID: 27019456. Impact factor = 2.8

Zhou R, Kang X, Tang B, Mohan C, Wu T, Peng A, Liu JY. Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics. Life Sci. 2016 Feb 1; 146:73-80. doi: 10.1016/j.lfs.2016.01.003. Epub 2016 Jan 8. PMID: 26773858 Impact factor = 2.7

Ding H, Kharboutli M, Saxena R, Wu T*. IGFBP-2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis. Clin Exp Immunol. 2016 Apr;184(1):11-8. doi: 10.1111/cei.12743. Epub 2016 Jan 11. PMID: 26616478. *Corresponding author. Impact factor = 3.409

Hinchliffe TE, Lin ZT, Wu T*. Protein arrays for biomarker discovery in lupus. Proteomics Clin Appl. 2016 Jan 22. doi: 10.1002/prca.201500060. [Epub ahead of print] Review. PMID: 26684273. *Corresponding author. Impact factor = 3.841

Jiang S, Hinchliffe TE, Wu T*. Biomarkers of An Autoimmune Skin Disease - Psoriasis. Genomics, proteomics & bioinformatics. 2015; PubMed [journal] PMID: 26362816 *Corresponding author. Impact factor = 6.615

Lin ZT and Wu T*. Theranostic Nanoparticles for Rheumatoid Arthritis. Reviews in Nanoscience and Nanotechnology 2015. Vol. 4, pp. 1–12. *Corresponding author.

Xu W, Wang L, Wang Q, Li XH, Hu D, Li C, Wu T, Mohan C, Peng A, Shi Y. Paraquat Poisoning Followed by Toxic Epidermal Necrolysis: A Report of Two Cases and Published Work Review. Dermatology. 2015 Jul 24. [Epub ahead of print] PMID: 26228174

Zhou CY, Kang X, Li CB, Li XH, Liu Y, Wang Z, Wang L, Wu T, Mohan C, Hu DY, Peng A. Pneumomediastinum predicts early mortality in acute paraquat poisoning. Clin Toxicol (Phila). 2015 Jul;53(6):551-6. doi: 10.3109/15563650.2015.1046183. Epub 2015 Jun 13. PMID: 26072933. Impact factor = 3.673

Wang L, Cheng JF, Sun LP, Song YX, Guo LH, Xu JM, Wu T, Mohan C, Peng A, Xu HX, Liu XY. Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease. Biomed Res Int. 2015;2015:732317. doi: 10.1155/2015/732317. Epub 2015 May 26. PMID: 26106613 Impact factor = 2.476

Qin L, Tang B, Deng B, Mohan C, Wu T, Peng A. Extracellular regulated protein kinases play a key role via bone morphogenetic protein 4 in high phosphate-induced endothelial cell apoptosis. Life Sci. 2015 Apr 18. pii: S0024-3205(15)00210-6. doi: 10.1016/j.lfs.2015.03.017. [Epub ahead of print] PMID: 25896660. Impact factor = 2.7

Kang X, Hu DY, Li CB, Li XH, Fan SL, Liu Y, Tang GY, Ai ZS, Wu T, Mohan C, Zhou XJ, Liu JY, Peng A. The Volume Ratio of Ground Glass Opacity in Early Lung CT Predicts Mortality in Acute Paraquat Poisoning. PLoS One. 2015 Apr 1;10(4):e0121691. doi: 10.1371/journal.pone.0121691. eCollection 2015. PMID: 25830638 Impact factor = 2.8

Wang L, Wu J, Cheng JF, Liu XY, Ma F, Guo LH, Xu JM, Wu T, Mohan C, Peng A, Xu HX, Song YX. Diagnostic value of quantitative contrast-enhanced ultrasound (CEUS) for early detection of renal hyperperfusion in diabetic kidney disease. J Nephrol. 2015 Feb 25. [Epub ahead of print] PMID: 25712236 Impact factor = 2.153

Zheng D, Li C, Wang S, Cang Y, Song Y, Liu X, Li X, Mohan C, Wu T, Hu D, Peng A. Life Sci. 2015 Jan 12. pii: S0024-3205(15)00006-5. doi: 10.1016/j.lfs.2014.12.023. [Epub ahead of print] PMID: 25592138 Impact factor = 2.7

Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li QZ, Mohan C*, Wu T*. Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol. 2015 Mar;179(3):435-43 doi: 10.1111/cei. 12473. [Epub ahead of print] PMID: 25345756, *Corresponding authors. Impact factor = 3.409

Wu T, Ye Y, Min SY, Zhu J, Khobahy E, Zhou J, Yan M, Hemachandran S, Pathak S, Zhou XJ, Andreeff M, Mohan C. Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid. Arthritis Rheumatol. 2014 Nov;66(11):3129-39. doi: 10.1002/art.38782. [Epub ahead of print] PMID: 25047252. Impact factor = 7.8

Wang L, Cheng J, Sun LP, Song YX, Guo LH, Xu JM, Wu T, Mohan C, Peng A, Xu H, Liu XY. Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease. BioMed Research International 2014. ID 732317. Impact factor = 2.476

Wang S, Qin L, Wu T, Deng B, Sun Y, Hu D, Mohan C, Zhou XJ, Peng A. Elevated cardiac markers in chronic kidney disease as a consequence of hyperphosphatemia-induced cardiac myocyte injury. Med Sci Monit. 2014 Oct 25;20:2043-53.

Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS.SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature. PLoS One. 2013 Jun 24;8(6):e67003. (Impact factor: 3.534)

Wu T*, Du Y, Han J, Singh S, Xie C, Guo Y, Zhou XJ, Ahn C, Saxena R, and Mohan C*. Urinary Angiostatin - a novel marker of renal pathology chronicity in lupus nephritis. Molecular and cellular Proteomics 2013 Jan 23. May; 12(5):1170-9. [Epub ahead of print] PMID: 23345539. *Corresponding authors. (Impact factor: 7.254)

Min S, Yan M, Du Y, Wu T, Khobahy E, Kwon S, Taneja S, Bashmakov A, Mohan C. Intra-articular Nf-kB Blockade Ameliorates Collagen‐induced Arthritis in Mice by Eliciting Regulatory T Cells and Macrophages Clinical & Experimental Immunology. Pub ahead of print: Jan 2013, DOI: 10.1111/cei.12054. (Impact factor: 3.278)

Vanarsa K, Ye Y, Han J, Xie C, Mohan C*, Wu T*. Inflammation associated anemia andferritin as disease markers in systemic lupus erythematosus. Arthritis Res Ther. 2012 Aug 7;14(4):R182. [Epub ahead of print] PMID:22871034. * Corresponding author. (Impact factor: 4.302)

Wu T, Mohan C. Lupus nephritis - alarmins may sound the alarm? Arthritis Res Ther. 2012 Dec 31;14(6):129. (Impact factor: 4.302)

Singh S*, Wu T*, Xie C, Vanarsa K, Han J, Mahajan T, Oei HB, Ahn C, Zhou XJ, Putterman C, Saxena R, Mohan C. Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis. Arthritis Res Ther. 2012 Jul 13;14(4):R164. [Epub ahead of print] PMID:22788914 *Joint first authors. (Impact factor: 4.302)

Yang Y, Ye Y, Liang L, Wu T, Zhan Z, Yang X, Xu H.Systemic-lupus-erythematosus-related acute pancreatitis: a cohort from South china. Clin Dev Immunol. 2012;2012:568564. Epub 2012 Jun 19. PMID:22761631 (Impact factor: 3.046)

Wu T, Xie C, Han J, Ye Y, Weiel J, Li Q, Blanco I, Ahn C, Olsen N, Putterman C, Saxena R.Mohan C. (2012) Metabolic Disturbances Associated with Systemic Lupus Erythematosus. PLoS ONE 7(6): e37210. PMCID: PMC3378560. (Impact factor: 3.73)

Min SY, Fu Y, Hutcheson J, Wu T, Khobahy E, Zhu J, Vanarsa K, Du Y, Park MJ, Park HS, Saxena R, Kim HY, Mohan C.Peritoneal catheter implantation elicits IL-10-producing immune-suppressor macrophages through a MyD88-dependent pathway. Clin Immunol. 2012 Apr;143(1):59-72. (Impact factor: 3.73)

Kiani A*, Wu T*, Fang H, Zhou XJ, Ahn C, Magder LS, Mohan C, Petri M. (2012) Urinary Vascular Cell Adhesion Molecule (VCAM-1) but not Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Lupus Nephritis. J Rheumatol. 2012 Jun;39(6):1231-7. Epub 2012 Apr 15. PMID: 22505707.* Joint first authors. (Impact factor: 3.187)

Ma F, Cang Y, Zhao B, Liu Y, Wang C, Liu B, Wu T, Peng A. (2012) Contrast-Enhanced Ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage. Nephrol Dial Transplant. 2012 Jul;27(7):2891-8. Epub 2012 Apr 24. PMID:22532616 (Impact factor: 3.371)

Peng, A*, Wu, T*, Zeng, C, Rakheja, D, Zhu, J, Ye, T., Hutcheson, J, Vaziri, ND, Liu, Z, Mohan, C, Zhou, XJ. (2011) Adverse Effects of Simulated Hyper- and Hypo-Phosphatemia on Endothelial Cell Function and Viability. PLoS One. 2011; 6(8): e23268. * Joint first authors. PMCID: PMC3153490 (Impact factor: 3.092)

Lu H*, Zhen J*, Wu T*, Peng A, Ye T, Wang T, Yu X, Vaziri ND, Mohan C, Zhou XJ. (2010) Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody induced glomerulonephritis in mice. Am J Physiol Renal Physiol. 299 (2):445-452. *Joint first authors. (Impact factor: 3.61)

Wu, T., Sajitharan, D., Mohan, C. Biomarkers of rheumatoid arthritis: recent progress. Expert Opinion on Medical Diagnostics. 2010. 4(4): 293-305.

Wu T, Fu Y, Brekken D, Yan M, Zhou XJ, Vanarsa K, Deljavan N, Ahn C, Putterman C, Mohan C. (2010) Urine proteome scans uncover total urinary protease, Prostaglandin D synthase, Serum amyloid P, and Superoxide dismutase as potential markers of lupus nephritis. J Immunol. 2010, 184(4):2183-93. PMCID: PMC2927858 (Impact factor: 5.26)

Santiago-Raber ML, Dunand-Sauthier I, Wu T, Li QZ, Uematsu S, Akira S, Reith W, Mohan C, Kotzin BL, Izui S. Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice. J Autoimmun. 2010 Jun;34(4):339-48. doi: 10.1016/j.jaut.2009.11.001. PMID: 19944565 (Impact factor: 8.136)

Wu, T., Mohan, C. (2009) The AKT axis as a therapeutic target in autoimmune diseases.. Endocrine, Metabolic & Immune Disorders - Drug Targets, 9(2):145-50.

Wu, T., Mohan, C. Proteomics as a tool for biomarker discovery in autoimmune diseases. 2009.Autoimmun Rev. 8(7):595-8. PMID: 19393208. (Impact factor: 8.961)

Hutcheson J, Scatizzi JC, Siddiqui AM, Haines GK 3rd, Wu T, Li QZ, Davis LS, Mohan C, Perlman H. (2008) Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity. 2008. Immunity 28, 206–217. PMID: 18275831 (Impact factor: 24.082)

Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, Mackay M, Aranow C, Putterman C, Mohan C. (2007). Elevated urinary VCAM-1, P-selectin, sTNFR-1 and CXCL16 in multiple lupus strains and human lupus nephritis. The Journal of Immunology, 179(10):7166-75. PMID: 17982109 (Impact factor: 5.26)

Wu T, Qin X, Kurepa Z, Kumar KR, Liu K, Kanta H, Zhou XJ, Satterthwaite AB, Davis LS, Mohan C. (2007). Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus. The Journal of Clinical Investigation, 117(8): 2186–2196. PMCID: PMC1913486 (Impact factor: 12.784)

Xie C, Patel R, Wu T*, Zhu J, Henry T, Bhaskarabhatla M, Samudrala R, Tus K, Gong Y, Zhou H, Wakeland EK, Zhou XJ, Mohan C. (2007). PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr. Int Immunol. 19(4):509-22. (*Joint First Authorship) (Impact factor: 3.748)

Wu T, Xie C, Bhaskarabhatla M, Yan M, Leone A, Chen SS, Zhou XJ, Putterman C, Mohan C. (2007). Excreted urinary mediators in immune nephritis with potential pathogenic significance. Arthritis & Rheumatism, 56(3): 949-959. PMID: 17328072

Wu T, Mohan C. 2007. Three pathogenic determinants in immune nephritis − anti-glomerular antibody specificity, innate triggers and host genetics. Frontiers in Biosciences, 12, 2207-2211. PMID: 17127457

Wu T and Mohan C. 2007. Proteomics on the diagnostic horizon-Lessons from Rheumatology. Am. J. Med. Sci. 333 (1): 16-25. PMID: 17220690

Mehrad B, Park SJ, Akangire G, Standiford TJ, Wu T, Zhu J, Mohan C. The lupussusceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol. 2006 Mar 1;176(5):3233-9. PMID:16493084 (Impact factor: 5.26)

Li QZ, Xie C, Wu T, Mackay M, Aranow C, Putterman C, Mohan C. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest. 2005 Dec;115(12):3428-39. PMCID: PMC1297234 (Impact factor: 12.784)

Vakonakis I, Sun J, Wu T, Holzenburg A, Golden SS, LiWang AC. NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: mplications for KaiAKaiC interaction. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1479-84. PMID: 14749515. (Impact factor: 9.661)

Wu T, Song L, Liu Y. Construction and analysis of a high-CO2-requiring mutant of the cyanobacterium Anabaena sp. strain PCC7120. Aust J Plant Physiol. 2000. 27(11) 1077 – 1083

Wu T, Song L, Liu Y. Selection and Ultrastructural Observation of a High-CO2-requiring Mutant of Cyanobacterium Synechococcus sp. PCC7942 . J. Integrative Plant Biology 2000 42(2): 116-121.

Wu T, Song L, Liu Y. Characterization of carboxysomal carbonic anhydrase in cyanobacterium Anabaena sp. PCC7120. Acta Hydrobiologica Sinica. 1999. 25 (5): 409-413

Wu T, Song L, Liu Y. An inducible CO2 concentrating mechanism in cyanobacterium Anabaena sp. strain PCC7120. 1999. Science Bulletin 44(23):2177-2181.

Wu T, Song L, Liu Y. Physiological aspects of a high-CO2 requiring mutant and the high-CO2 growing cells of the cyanobacterium Synechococcus sp. PCC7942. Chinese Journal of Oceanology and Limnology. 1998; 16:133-139.