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Biomolecular Engineering for Genome Editing and Nanomedicine

Speaker
Gang Bao, Ph.D.
Date
Location
SEC 204
Abstract
The integration of biomolecular engineering, nanotechnology and biology is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures with proteins and nucleic acids, the design, optimization and application of nanoprobes, nanocarriers and molecular machines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection and therapy. Recent advances include the development of engineered nucleases and multi-functional nanoparticles for biological and medical applications.

In this talk I will present the design and optimization of CRISPR/Cas9 systems for treating single-gene disorders, and the development and application of multi-functional nanoparticles for molecular imaging, cell tracking and biomolecule detection. The opportunities and challenges in nanomedicine and therapeutic genome editing are also discussed.