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Label-free Brain Imaging and Mapping with a Serial Optical Coherence Scanner

Speaker
Taner Akkin, Ph.D.
Date
Location
Zoom
Abstract
Serial optical coherence scanner provides intrinsic optical contrasts for large-scale brain imaging and mapping at microscopic resolution. It distinguishes white matter and gray matter, and visualizes exquisite networks of axon fiber tracts. This is achieved by using the polarization contrasts highlighting the myelinated fibers and their alignment, and the conventional reflectivity contrast that is available for studying the gray matter. The scanner is a tool for basic and applied research into the structural and connectional architecture of the brain. In addition to imaging applications on brain diseases and conditions, the connectivity maps and principles this technology identifies have potential to guide neuromodulation treatments. If time permits, Dr. Akkin will present a summary of another study that is on optical imaging of neural action potentials.