Importance of Math Models in Uncovering Mechanisms in Alzheimer’s Disease NSF’s Investments in Biotechnology & Bioeconomy

Theresa Good, Ph.D.
University of Houston
I’ve had the good fortune to have a career in science and science policy that has enabled me
to tackle important problems using tools from my training as an engineer. Mathematical
modeling to elucidate mechanisms and help set experimental direction has been key in my
group’s efforts in solving problems associated with Alzheimer’s disease. I’ll review some of
our early work in using models to understand mechanisms of beta amyloid interaction with
neurons as well as later work understanding the importance of beta amyloid structure in
toxicity. I’ll also provide highlights from our most recent work in examining the impact of 3D
culture on Alzheimer’s models. Then I’ll provide an overview of NSFs investments in
biotechnology and the bioeconomy, one of the industries of tomorrow that can contribute to
the US economic recovery, and mention some current funding opportunities that target
postdocs, early and mid-career professionals, as well as opportunities for all investigators.