Structural and Functional Imaging with Optical Coherence Tomography

Manmohan Singh, Ph.D.
Optical coherence tomography (OCT) is a noninvasive imaging technique capable of crosssectional
imaging at micrometer scale resolution. Since its formal introduction in 1991, OCT has
expanded beyond its initial use in ophthalmology to other fields like dermatology, pulmonology,
and developmental biology because of its rapid imaging speed, noninvasive nature, and high
resolution. For developmental biology in particular, OCT has rapidly gained traction because it
does not require any exogenous contrast agents and can be readily used without extensive
sample preparation protocols. I will show some of our recent work using structural and
functional OCT to answer various questions in developmental biology.