Brain Controllability Analysis

Feng Fang
Brain neuromodulation effectively treats neurological diseases such as Depression. However,
due to the patient heterogeneity, neuromodulation treatment outcomes are often highly
variable, requiring patient-specific stimulation targets and parameters by accommodating
inherent variability and intersession alteration during treatments. To address this gap, we
developed a personalized transcranial magnetic stimulation (rTMS) protocol and evaluated its
feasibility in optimizing the treatment efficacy using an existing dataset from an
antidepressant experimental imaging study in depression. The personalization of the rTMS
treatment protocol was achieved by personalizing both stimulation targets and parameters via
integrating the brain controllability analysis and optimal control analysis. Our results support
the feasibility of developing personalized neuromodulation protocols to more efficiently treat
depression and the utility of brain controllability analysis in understanding neural control
mechanisms of various neurological and psychiatric diseases.